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Unveiling the Bioinformatics R2 Course: A Journey of Discovery with Amirhossein Masroor!

In March 2024, the Butterfly students followed a bioinformatics R2 course at the Amsterdam University Medical Center (AMC) coordinated by Jan Kooster. The web-based bioinformatics analysis and visualization platform R2, was developed in-house at the AMC. The course provided a comprehensive introduction to the platform’s capabilities and equipped the students with the skills necessary to harness its full potential in biomedical research. Through a combination of theoretical instructions and practical applications, the course introduced the breadth of data and practical tools gathered in R2.

The first day started with an insightful and comprehensive introduction to the various datasets and tools available on the R2 platform. Notably, there are training videos and a didactic tutorial book publicly available on the R2 platform. From genomic to transcriptomic datasets, the vast array of resources at one’s disposal combined with the knowledge of available tools on the platform could streamline one’s research was fascinating.

The afternoon program commenced with a practical application of the platform using a neuroblastoma tumor dataset made accessible for butterfly students for the 2-day course. Advantaging from a comprehensive instruction document, provided through GitHub documents, specifically tailored for the Butterfly program, the class delved into a collaborative practical example on finding prognostic factors, and finding causes in Neuroblastoma by identifying different expression patterns within subgroups.

As the course progressed into its second day, the class continued exploring the platform capabilities, through a second tailored instructional document, focusing on structural variants. This section was designed to discover new insight into pediatric neuroblastoma by combining whole genome sequencing and expression data.

The highlight of the course for me was the interactivity and self-learning nature of it. Under the guidance of Lieke Hoyng, and the dedicated bioinformatics team, support was readily available throughout the course to assist students with questions and navigate through the guidebook. The diverse range of research questions that could be answered using the R2 platform advancing knowledge in respective fields of study I found to be quite inspiring.

Further information on the R2 course can be found at

https://www.facebook.com/ r2 platform  and  https://twitter.com/ r2 _platform

To read about new functionalities and noteworthy datasets that get added to the genomics and visualization platform  R2r2 platform.com .