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den Boer Group

Celine Debou

Group: den Boer Group

About Celine

My name is Céline, I am 23 years old and I recently graduated from Ghent University (Belgium) with a Master’s degree in Biomedical Sciences, specializing in oncology. I chose the Butterfly program at the Princess Máxima Center because of the international approach and the opportunity to work in research directly linked to clinical practice.

My Project: ALL, leukemic niche and cell based immunotherapy

My PhD project focuses on the effect of the leukemic niche on immunotherapy in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). We will investigate and characterize the interplay of leukemic cells, mesenchymal stromal cells (MSCs) and immune cells using techniques such as spectral flow cytometry, flow sorting and live imaging. Additionally, we will model and manipulate the efficacy of immunotherapy in ex vivo multidimensional cultures, representing the complex interplay in the leukemic niche. Ultimately, we aim to help optimize immunotherapy for BCP-ALL.