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van Leeuwen Group

Eva Sofie Baum

Group: van Leeuwen Group

About Eva

I am a molecular biologist from Germany with a master’s degree in Biomolecular Engineering from the Technical University of Darmstadt, Germany. I was first introduced to oncology in my bachelors and started my studies with a broad interest in molecular targeted therapies, antibody engineering and immunotherapies. During my master’s I collaborated on a project on nanobody-targeted photodynamic therapy which I continued in the group of S. Oliveira after I graduated. During this time I decided that I want to proceed my studies in translational research in oncology.

My Project: Metabolic targeting of T-cell Acute Lymphoblastic Leukemia to identify more effective, less toxic treatment options

Acute T-cell lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy in both children and young adults. In spite of a fairly favorable prognosis at diagnosis, T-ALL relapsed poses an ongoing treatment challenge as well as an unmet clinical need. Therefore, the project will focus on defining metabolic dependencies in T-ALL. The advantage of metabolic therapies over classical chemotherapy is the absence of long-term genotoxicity, which is particularly important for (young) children.