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Group: Kool Group

About Julie

I am originally from Belgium but achieved a Bachelor’s and Master’s degree in Biochemistry at the University of Mainz in Germany. During my Bachelor’s degree, I focused on elucidating the cellular functions of a protein that potentially serves as a prognostic biomarker in pediatric acute lymphoblastic leukemia. For my Master’s thesis, I investigated the role of post-translational modifications in the pathogenesis of Alzheimer’s disease. I have always had a great passion for oncology research and therefore decided to pursue a PhD in this field.

My Project: R-loops in pediatric brain tumors: from cause to cure?

I am focused on elucidating the role of R-loops within the context of pediatric brain tumors. R-loops are DNA:RNA hybrid structures that under physiological conditions serve as dynamic recruitment platforms to facilitate various essential functions within the cell. Persistence and accumulation of R-loops as a result of deregulated formation or resolution, however, pose a threat to genomic integrity and can potentially trigger cascades that transform a healthy cell into a cancer cell. So far, little is known about the origin and regulation of R-loops in brain tumors.