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Belderbos Group

Patrycja Fryzik

Group: Belderbos Group

About Patrycja 

I was born in Warsaw, Poland, where I also grew up and studied. For university, I moved to the UK, where I completed an integrated Master’s degree in Medical Sciences at the University of Leeds, with a thesis on bacterial protein structures and their related activity. There, I also expanded my knowledge and interest in cancer biology, which led me towards wanting to continue my education in leukemic research and applying for the Butterfly project in the Princess Maxima Center.

My Project: A life without blood: Single-cell analysis of childhood myelodysplastic syndrome to uncover therapeutic targets.

My project will focus on the investigation into the clonal evolution of pediatric myelodysplastic syndrome (MDS), which is a pre-cancerous condition characterized by the abnormal hematopoietic stem cell function and high risk of disease progression to acute myeloid leukemia (AML). Currently, the primary treatment available is chemotherapy and an allogeneic stem cell transplantation, which carries significant risks. My project will utilize single-cell RNA sequencing and in vitro cultures, to gain insight into molecular mechanisms and pathways underlying MDS, its therapeutic vulnerability, as well as its progress to AML.