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Drost group

Rugile Januskeviciute

Group: Drost Group

About Rugile

• I am from Vilnius, Lithuania.
• BSc Biomedical Sciences at the University of Manchester and MSc Cancer Biology at Imperial College London and London Institute of Medical Sciences.
• In my Masters I explored the effects of aging and gender on colorectal cancer development and tested the effect of novel AKT/PI3K pathway inhibitors on ovarian cancer organoid models.
• Completed industrial placement year on epigenetics and deep learning at GlaxoSmithKline.

My Project: Characterization of the immune microenvironment of rhabdomyosarcoma for the development of immunotherapy

• Pediatric rhabdomyosarcoma (RMS) is a soft tissue
malignancy of mesenchymal origin.
• The cellular differentiation states underlying RMS, its immune microenvironment, and how these relate to patient outcomes remains unknown.
• Using single-cell omics approaches to characterize the differentiation stages and immune landscape of RMS.
• Functional validation of potential therapeutic targets using patient-derived RMS organoid models and immune cell co-culture models.